I have constant tight pain in my chest/throat. ppis ineffective, endo/manometry/ph all negative for gerd, and cardio tests/echo all normal. what next?

Functional condition: The major issues have been ruled out; so this may be a functional problem, similar to irritable bowel syndrome; some form of biofeedback therapy may be helpful to get control of the situation.

Spasm/anxiety: Does it affect your breathing? Esophageal spasm/ asthma/ anxiety are all possibilities.Talk to your doc about your persistent symptoms.