A member asked:

I want a hematologist opinion pls tel me why n how is there a m spike when protein albumin globulin ag ratio all are in good range?

A doctor has provided 1 answer
Dr. Eric Chevlen answered

Specializes in Internal Medicine - Oncology

See explanation: An M spike describes a monoclone (single type) of immunoglobulin. (Ig) If the rest of the normal globulins are low, but there is an excess of one type of Ig, then the ratio of albumin to (total) globuline can still be normal despite presence of an M spike.

Answered 7/30/2014

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