A member asked:

My globulin level is 1.6 (low) and albumin/globulin ratio is 2.9 (high). my protein total random ur is less than 4 (low). my kidney/liver function both tested out fine. what is the likely cause of these ratios being out of the reference range?

6 doctors weighed in across 3 answers
Dr. Sue Ferranti answered

Specializes in Internal Medicine

Since your globulin level is low, the albumin/globulin ratio would be high since it is a fraction and the denominator is low-this would make the ratio itself high. See the doctor who ordered the tests to review them. There are many causes of low protein levels, including dietary intake. So, see your doctor for diagnosis/treatment. Good luck!

Answered Jul 21, 2022

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Dr. Gurmukh Singh answered

Specializes in Pathology

All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Talk to the doctor who ordered the tests. Having said that, a globulin level of 1.6 is not a cause for concern. the high ratio notwithstanding. Wish you good health!

Answered Jul 19, 2022

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Dr. Donald Colantino answered

Specializes in Internal Medicine

Since your globulin level is less than 2 and you have protein in your urine,I recommend that you have an accurate determination of how much protein you lose in a 24 hour collection of urine as heavy proteinuria is a cause of low globulin. While you're at it, have an immunofixation test of the urine in case your urine protein loss is high. You have ruled out liver disease as a cause though.

Answered Jul 20, 2022

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