A member asked:

Tested + for hsv 2 igm when i use to be positive for hsv 1 but now negative? should i be concerned?

5 doctors weighed in across 5 answers

Maybe: IgM antibodies usually appear shortly after infection. IgM antibodies typically begin to be detectable at 5-10 days after infection and phase out within a few months. A second type of antibody known as IgG antibodies will begin to develop shortly after infection. IgG antibodies are usually detectable at 4-12 weeks after exposure. You may have been exposed to HSV 2. Best wishes.

Answered 7/28/2014

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Herpes...: When you get tested for infection IgM positive means recent infection. In this case herpes type 2 is usually found in the genital area and is sexually transmitted. If you get symptoms like painful,itchy blisters or lesions you should get seen for further evaluation and treatment.

Answered 7/28/2014

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No: Lab error?? Probably should repeat the test. Meanwhile discuss herpes simplex in detail with your DR. You need to be fully informed about how it affects you and what to do about it.

Answered 7/28/2014

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Yes: Its true that HSV1 can cross-react with the IgG assay and cause a false positive HSV2 test, this problem is much less likely with the IgM test. If IgM is psitive, you should conduct yourself as infected with HSV2, until you have a talk with your testing doctor about your TITER. Rember, its not just about you going on treatment, but also protecting your sexual partners.

Answered 7/28/2014

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If you have lesions: Both HSV 1 and 2 may lay quiet in the a nerve root and become activated at different times. IgM antibodies are short term antibodies and often become undetectable after a short time, so if levels are positive, it doesn't tell if this is from a new infection or a reactivated infection, and many lab tests aren't sensitive to determine 1 vs 2. Most people get exposed to HSV by their 30's. Lesions?

Answered 12/3/2014

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