Is it normal for seroquel (quetiapine) to become less effective over time for sleep? should i increase the dose or try a different medication. i'm taking 300 now.

Yes: The use of Seroquel (quetiapine) for sleep is strictly 'off-label'. This is a side effect many like to use to their benefit for insomnia. This side effect dissipates in time for most people. If it is losing its 'ummph' I would advise seeing your doctor for a more appropriate sleeping treatment.

Seroquel (quetiapine) for sleep?: Seroquel (quetiapine) an atypical antipsychotic that should not be used, only to manage insomnia (as meds with fewer side shu be explored here. However, if u have a diagnosis of bipolar disorder, for which quetiapine is being used as a mood stabilizer, it's sedating effect can be used to treat insomnia. If you have worsening insomnia, c ur MD! This cld be a sign of worsening mood d/o & needs eval

Check with your MD: Adjustments to dosages of medications, especially one like Seroquel, (quetiapine) should be discussed first with your prescriber. Some people report that their medications become less effective for sleep over time. But before increasing dose ask -are there other factors that might be interfering with sleep? What is your sleep schedule like? Are there changes in your environment/habits/worry around sleep?

Talk to doctor: People often become tolerant to sedative effects of Seroquel (quetiapine). To the extent that the sleep difficulty is related to depression or bipolar disorder, it will diminish or go away with adequate treatment. The return of insomnia may reflect a change in your condition that could warrant dosage adjustment, or other medication changes. Please see your doctor.