A member asked:

I have bad insomnia since stop taking prozac and seroquel (quetiapine). i can only sleep now if i take seroquel (quetiapine). is this because i stop taking prozac 3 weeks ago. will i be able to sleep w/o taking seroquel (quetiapine) ever?

6 doctors weighed in across 3 answers
Dr. Shin Beh answered

Yes: You probably need to taper it rather than stop it cold turkey. Ask your doctor if he/she can prescribe alternative sleep aids.

Answered 6/4/2013

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Seroquel (quetiapine) withdrawal.: Seroquel has antihistamine (like Benadryl (diphenhydramine) has which is also very sedating). If stopped abruptly, it can cause antihistamine withdrawal and insomnia. If tapered slowly, (with smaller dose reductions over a couple of weeks), this should avoid this problem. Insomnia, due to anxiety or depression is a longer term issue. Discontinuation of an antidepressant like Prozac may contribute to this.

Answered 6/30/2014

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Dr. Andrew Hoffman answered

Specializes in General Surgery

Consider Melatonin: With your doctor. Only means to getting regular sleep will be with a considered/ balanced approach with all of your medicines. Your doctor should help you choose what will work best.

Answered 4/25/2016

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