Possibly: Any medicine can cause virtually any side effect. Aldactone (spironolactone) is a diuretic and they can affect your potassoim levels. Although Aldactone (spironolactone) is known to not affect potassium very much, it is a possibility that they could be related.
Answered 6/24/2014
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Doubt it: Spironolactone is a potassium-sparing diuretic, and leg cramping can come on with low potassium levels. Other causes are overuse of the muscles as with heavy exertion, prolonged standing/working on legs, venous incompetence.
Answered 6/15/2019
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