Long incubation : the incubation is very long for the carcinoma in situ. Why after this period of time the invasive lesion is so aggressive is undetermined. Early diagnosis in the incubation period of time can be made with ERCP brushing where the atypical preinvasive cells can be identified. Usually after 15 years the in-situ lesion transforms and invades the ductal wall into the parenchyma to become invasive.
Answered 6/18/2014
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