I am taking prednisone for an allergic reaction to azithromycin. can i take benadryl (diphenhydramine) before i sleep? will it help with this kind of allergic reaction?

Yes: Benadryl (diphenhydramine) will help with the allergic reaction.feel free to take the antihistamines

No answer: You left out the information needed to answer. Benadryl (diphenhydramine) may help if you have hives. If you do, there are much better antihistamines. If you want a sleeping pill, use Benadryl (diphenhydramine). DO NOT TAKE BENADRYL (diphenhydramine) IF YOU DRIVE. It is dangerous to be sleepy and drive. If you have a rash, not hives, no antihistamine will make the slightest difference.