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A 19-year-old female asked:

7wks pregnant, is prednisone safe for treating my 1st time hives 3 days going, benadryl (diphenhydramine) seems to calm it, appears after 8 hrs effect, is this safe?

1 doctor answer2 doctors weighed in
Dr. Felecia Sumner
Family Medicine 11 years experience
Not really safe: Studies suggest that there's a small increased risk of oral clefts when taking Prednisone in the first trimester. An oral cleft happens when the lip or palate (roof of the mouth) does not fully close during development. Before you take prednisone, discuss other options with your healthcare provider. There are other medicines available that may be safer and still keep your hives under control.
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Last updated Jun 21, 2015

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