Novel anticoagulants: There have been 3 "warfarin substitutes" since 2010 that have FDA approval for venous thromboembolism prevention, treatment of venous thromboembolism, or stroke prevention in atrial fibrillation . They include the oral direct thrombin inhibitor dabigatran, and the oral direct factor Xa inhibitors rivaroxaban and apixaban. All agents have predictable pharmacokinetic profiles and do not require monitoring
Answered 2/5/2017
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