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A member asked:
Can nephroblastoma start out with favorable histology, but for some reason, turn anaplastic? any help appreciated!
A doctor has provided 1 answer
Histo can change: Survival with nephroblastoma will change with duration and nodal status. Children with Wilms tumor (nephroblastoma) who have a particular risk of failure at relapse or at primary diagnosis where at least 15% presented with regional nodal metastasis should be treated with high-dose chemotherapy (HDC) and autologous peripheral blood stem cell rescue if needed. Nearly ½ will remain NED at 5 yrs.
Answered 7/28/2014
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