Can you tell me how metformin differ from glimepiride in terms of functionality in case of type 2 diabetes ?

Different classes: Hi. Metformin is a so-called Insulin sensitizer and makes primarily the liver more responsive to Insulin so glucose is stored instead of released into the blood. It doesn't stimulate Insulin release, and by itself can't cause low blood sugar. Glimepiride stimulates Insulin release from the cells that make it in the pancreas. It raises Insulin levels and can cause low blood sugar.