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A 44-year-old member asked:

How does cymbalta (duloxetine) work?

4 doctor answers8 doctors weighed in
Dr. Susan Uhrich
Psychiatry 37 years experience
Cymbalta (duloxetine): Is an nsri, or a norepinephrine/serotonin reuptake inhibitor. This means that Cymbalta (duloxetine) slows the breakdown of both of these neurotransmitters, which allows them to have a longer effect.
Dr. Alan Ali
Dr. Alan Alianswered
Psychiatry 33 years experience
Cymbalta (duloxetine): It's actions on norepinephrine & serotonin helps releave symptoms of depression & fibromyalgia.
Dr. Susan Grossbard
24 years experience
Terrible side effect: Side effects are horrrific.
Dr. Alan Ali
Dr. Alan Ali commented
Psychiatry 33 years experience
Sorry, but the question was not about side-effects!
Dec 1, 2012
Dr. Mark Reynolds
Psychiatry 34 years experience
Very well for many: Cymbalta (duloxetine) is a serotonin-norepinephrine specific reuptake inhibitor- a medication that blocks the reuptake of these chemicals from the synapse, the area between two nerve cells (axon and dendrite). This leads to changes that would take way more than 400 characters to describe. Essentially it helps the brain to process information better, decreasing depression, anxiety and pain in many patients.

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Similar questions

Saint Petersburg, FL
A 62-year-old female asked about a 66-year-old male:

What is cymbalta (duloxetine)?

4 doctor answers9 doctors weighed in
Dr. Ruth Seaman
A Verified Doctoranswered
Psychiatry 27 years experience
A multi-use medicine: Duloxetine increases the amount of norepinephrine and serotonin in the tiny space between neurons for a few microseconds. More importanly for the treatment of depression, is the actual internal response by the cell binding the medication which takes 3-6 weeks or more for full effect. This medicine is further known to help reduce pain transmission up the spinal cord as well.
Last updated Nov 4, 2016
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