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A 44-year-old member asked:

how does cymbalta (duloxetine) work?

4 doctor answers8 doctors weighed in
Dr. Susan Uhrich
Psychiatry 36 years experience
Cymbalta (duloxetine): Is an nsri, or a norepinephrine/serotonin reuptake inhibitor. This means that Cymbalta (duloxetine) slows the breakdown of both of these neurotransmitters, which allows them to have a longer effect.
Dr. Alan Ali
Dr. Alan Alianswered
Psychiatry 32 years experience
Cymbalta (duloxetine): It's actions on norepinephrine & serotonin helps releave symptoms of depression & fibromyalgia.
Dr. Susan Grossbard
Clinical Psychology 23 years experience
Terrible side effect: Side effects are horrrific.
Dr. Alan Ali
Dr. Alan Ali commented
Psychiatry 32 years experience
Sorry, but the question was not about side-effects!
Dec 1, 2012
Dr. Mark Reynolds
Psychiatry 33 years experience
Very well for many: Cymbalta (duloxetine) is a serotonin-norepinephrine specific reuptake inhibitor- a medication that blocks the reuptake of these chemicals from the synapse, the area between two nerve cells (axon and dendrite). This leads to changes that would take way more than 400 characters to describe. Essentially it helps the brain to process information better, decreasing depression, anxiety and pain in many patients.

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A 29-year-old member asked:

Are generic versions of duloxetine as safe as the brand name drug?

2 doctor answers2 doctors weighed in
Dr. Kevin Considine
Family Medicine 30 years experience
Yes: Yes generic versions of duloxetine should be safe along with any other generics although i'm not sure that a generic of duloxetine is available yet?
CA
A 46-year-old member asked:

Does it make a difference whether I take my cymbalta (duloxetine) in the night or the morning?

4 doctor answers7 doctors weighed in
Dr. Barbara A Majeroni
Specializes in Family Medicine
Morning is better: Taken in the evening, Cymbalta (duloxetine) can cause insomnia, so it is better to take it in the morning.
CA
A 27-year-old member asked:

How quickly is it safe to increase my dose of cymbalta (duloxetine)?

3 doctor answers6 doctors weighed in
Dr. Leonard Raucher
Specializes in Family Medicine
1 weeks: You may safely increase Cymbalta (duloxetine) on a weekly basis.
CA
A 37-year-old member asked:

Will cymbalta (duloxetine) make me feel better right away?

1 doctor answer3 doctors weighed in
Dr. Alfredo Soto
Psychiatry 26 years experience
No: The effects of Cymbalta (duloxetine) will take from 1 week to 1 month depending on why you are using it. It can help symptoms of pain in 1-2 weeks, and depression in 1-4 weeks. It usually takes longer for Cymbalta (duloxetine) to help symptoms of anxiety.
A 29-year-old member asked:

What is duloxetine prescribed for?

2 doctor answers12 doctors weighed in
Dr. Alan Ali
Dr. Alan Alianswered
Psychiatry 32 years experience
Cymbalta (duloxetine): Used for major depressive disorder, generalized anxiety disorder, stress urinary incontinence, painful peripheral neuropathy such as in diabetes, fibromyalgia, chronic musculoskeletal pain associated with osteoarthritis, lower back pain, interstitial cystitis, chronic fatigue syndrome.

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Last updated Nov 4, 2016

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