Are there any medications that can make rls worse?

Several: Antidepressants (prozac, paxil, (paroxetine) and others), antipsychotics (risperdol, seroquel and others), certain anti-nausea meds (metachlopramide), and sedating antihistamines (benadryl) can all aggravate restless leg syndrome (rls). However, these medications may not be able to be discontinued. Some meds may be substituted for others in the same class. Caffeine, nicotine, and alcohol may also worsen rls.

Mostly 4 types: Antihistamines, antidepressants, Dopamine antagonists and any stimulants (including caffeine and nicotine).