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A 32-year-old member asked:

Can you tell me if throughout alcohol abuse, why does clotting and excessive bruising occur when alcohol damages hepatocytes (liver cells)?

2 doctor answers9 doctors weighed in
Dr. Michael Gabor
Diagnostic Radiology 34 years experience
Alcohol: affects multiple organ systems, not just the liver. To your question, though, fibrinogen and other clotting factors are produced in the liver. Alcohol interferes with their production and activity in various ways, to the effect that alchol has both a procoagulant(which would increase clotting) and anticoagulant(the opposite) effects. Whichever pathway dominates will determine the net effect.
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Dr. Ruth Seaman
A Verified Doctor commented
A US doctor answered Learn more
Additional effect of alcohol directly suppressing bone marrow production of platelets
Jul 18, 2014
Dr. Alan Wartenberg
A Verified Doctoranswered
Addiction Medicine 50 years experience
Not just liver cells: liver cells produce clotting proteins that are derived from Vitamin K, as well as several others, and the absence of these proteins can lead to easy bruising and bleeding. In addition, alcohol effects the blood cells that promote clotting (platelets or thrombocytes) and this further causes easy bruising/bleeding. Finally it weakens the walls of the tiny blood vessels themselves.
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Similar questions

A 38-year-old member asked:

Why does clotting and excessive bruising occur in hepatocytes (liver cells) during alcohol abuse?

1 doctor answer2 doctors weighed in
Dr. Gurmukh Singh
Pathology 50 years experience
Metabolic toxin: Alcohol produces a number of metabolic effects that damage liver cells, cause fat accummulation in liver, liver cell necrosis/death, cirrhosis and liver cancer. Clotting and bruising are not medical terms with reference to hepatocytes.
Created for people with ongoing healthcare needs but benefits everyone.
Last updated Apr 7, 2016


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