A member asked:

Can you tell me if throughout alcohol abuse, why does clotting and excessive bruising occur when alcohol damages hepatocytes (liver cells)?

9 doctors weighed in across 2 answers
Dr. Michael Gabor answered

Specializes in Diagnostic Radiology

Alcohol: affects multiple organ systems, not just the liver. To your question, though, fibrinogen and other clotting factors are produced in the liver. Alcohol interferes with their production and activity in various ways, to the effect that alchol has both a procoagulant(which would increase clotting) and anticoagulant(the opposite) effects. Whichever pathway dominates will determine the net effect.

Answered 4/7/2016

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Not just liver cells: liver cells produce clotting proteins that are derived from Vitamin K, as well as several others, and the absence of these proteins can lead to easy bruising and bleeding. In addition, alcohol effects the blood cells that promote clotting (platelets or thrombocytes) and this further causes easy bruising/bleeding. Finally it weakens the walls of the tiny blood vessels themselves.

Answered 10/27/2014

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