Yes: Lithium is a mood stabilizer that prevents episode of mania (folloed by depression) where as zoloft (sertraline) is an antidepressant (not a mood stabilizer) if you have bipolar disease taking zoloft (sertraline) without lithium could precipitale a manic episode. I don;t advise making any canges if you are taking both without consulting with your psyciatrist.
Answered 5/3/2014
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