A member asked:

Is selegiline effective as azilect (rasagiline) for parkinsons?

10 doctors weighed in across 3 answers
Dr. Colin Sanner answered

Specializes in Neurology

MAO-B inhibitors: Both selegiline (eldepryl) and Rasagiline (azilect) are mao-b inhibitors, with a couple important differences. Azilect (rasagiline) is much more specific for mao-b, meaning no risk of serotonergic crisis when used alongside ssri antidepressants (celexa, lexapro, etc). Azilect (rasagiline) is also the only neuroprotective drug for parkinson's. Take care!

Answered 10/1/2020

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"Effective"-misleads: "effective" misleads since nothing but nothing is as effective as the gold standard Levodopa to treat parkinson's. ; especially when talking about selegiline ; Azilect (rasagiline) which are designed to maintain stability ; shouldn't be prescribed under the notion that symptoms are expected to improve. Bottom line? I've not seen much difference using or not using either agent in terms of improving symptoms.

Answered 6/27/2014

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PERSPECTIVE: My other colleagues are very correct in that neither drug independently has much of a chance either controlling or slowing the progression of parkinson's, but may well enhance the effect of l-dopa. Have found that Azilect (rasagiline) is better tolerated than selegiline, but latter is less expensive. Note you have had dbs, and at this point would be skeptical that either product will benefit you.

Answered 6/24/2014

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