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A member asked:
Ana 1280. dsdna 23 iu/ml (<40 is neg), other ena neg. not yet tested for histone. have some symptoms. is dsdna significant here? developing sle?
A doctor has provided 1 answer
No: Many patients with lupus only have a positive ANA with all other autoantibodies being negative. If the dna was positive, it is more specific for lupus than the ana. The histone is less valuable unless you are screening for a drug induced lupus.
Answered 6/10/2014
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I'm symptomatic, ANA & anti-dsdna neg. W/ a strong family history of sle. Is it worth doing further testing like anti-sm (neg. For infection and iem)?
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ANA result came back as 1:640 homogenous pattern. Anti-dsDNA Antibodies came back negative. I have a lot of lupus symptoms. If the Anti-dsDNA Antibodies came back negative, does this mean it's likely not Lupus? Also had TPO antibodies present at 70?
3 doctors weighed in across 2 answers
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