Is lipozene safe to take with prozac, topamax, and xanax (alprazolam)?

Yes: I would take it at a separate time from the medications so it does not affect the absorption of the medications.

Multiple drugs: I feel it's best for you to check with your physicians and your pharmacist as the latter has the access to that type of information about drug interactions and the physicians who prescribe that combination of medications have real experience with them.