A member asked:

Severe joint/muscle pain/neuropathy. rheumo tested labs again. complement c3 213. ss-a 1.4. diangosis w sjogrens via biopsy. what does the high c3 mean. have ms, hasimotos, raynauds etc. all other tests-.

4 doctors weighed in across 3 answers

Nothing: High complement levels have no clinical significance.

Answered 12/6/2015

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Dr. Jan Lei Iwata answered

Specializes in Ophthalmology

Auto immune profile : Your results point toward autoimmune diseases. The sjogrens, hashimoto's, ms, other findings are consistent with this, including a high complement level. So, don't forget to get an ophthalmologic examination done with dilated funduscopic exam, dry eye testing, and also ENT evaluation to see if you have sjogrens affecting your salivary glands. I'm glad you're getting the full work up.

Answered 4/26/2018

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High C3: C3 plays an important role in the immune system and a high level signifies the presence of inflammatory processes which C3 mediates.

Answered 1/31/2020

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