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Saint Paul, MN
A 50-year-old female asked:

Severe joint/muscle pain/neuropathy. rheumo tested labs again. complement c3 213. ss-a 1.4. diangosis w sjogrens via biopsy. what does the high c3 mean. have ms, hasimotos, raynauds etc. all other tests-.

3 doctor answers4 doctors weighed in
Dr. Ronald Krauser
A Verified Doctoranswered
Rheumatology 54 years experience
Nothing: High complement levels have no clinical significance.
Created for people with ongoing healthcare needs but benefits everyone.
Dr. Jan Lei Iwata
Dr. Jan Lei Iwataanswered
Ophthalmology 28 years experience
Auto immune profile : Your results point toward autoimmune diseases. The sjogrens, hashimoto's, ms, other findings are consistent with this, including a high complement level. So, don't forget to get an ophthalmologic examination done with dilated funduscopic exam, dry eye testing, and also ENT evaluation to see if you have sjogrens affecting your salivary glands. I'm glad you're getting the full work up.
Created for people with ongoing healthcare needs but benefits everyone.
Dr. Donald Colantino
Internal Medicine 63 years experience
High C3: C3 plays an important role in the immune system and a high level signifies the presence of inflammatory processes which C3 mediates.
Created for people with ongoing healthcare needs but benefits everyone.
Last updated Jan 31, 2020

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