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A 49-year-old male asked:

Why does tegretol reduce the effectiveness of klonopin (clonazepam) by 30% but not ativan?

1 doctor answer5 doctors weighed in
Dr. Pamela Pappas
Psychiatry 43 years experience
Klonopin (clonazepam) vs Ativan: Tegretol induces the metabolism of drugs which are metabolized by the liver enzyme cyp 3a4. Klonopin (clonazepam) is one of these drugs, but Ativan is not. This means that in the presence of tegretol, Klonopin (clonazepam) may be metabolized faster than expected, reducing its effectiveness.
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Last updated Apr 17, 2016

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