Is it safe to take fluoxetine with parkinson's medications such as sinemet and requip (ropinirole)?

Mild interaction: There is no severe interaction although if the fluoxetine were to be sedating to you then you may feel somewhat sedated. Additionally, the selective serotonin reuptake inhibitors that include fluoxetine have been known to produce mild extrapyramidal effects through obscure mechanisms. This would translate into a potential for mild motoric phenomena that would be only a nuisance. Stay safe!