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A 40-year-old member asked:

Is it good to combine prozac with wellbutrin (bupropion) for treatment of depression?

3 doctor answers11 doctors weighed in
Dr. Glenn Archibald
Psychiatry 37 years experience
It is good, sort of.: It depends. There is no absolutes in medicine. However, it is not unusual to combine antidepressants if the initial does not work. Prozac and wellbutrin (bupropion) have been combined quite successfully to help many patients.
Dr. Douglas Bey
Psychiatry 57 years experience
May be: Wellbutin blocks the uptake of norepinephrine & Dopamine while Prozac (fluoxetine) is a ssris so they effect different neurotransmitters & may work 4 u.
Dr. Neil Liebowitz
Psychiatry 39 years experience
combo can be more effective than either alone.
Apr 24, 2012
Dr. Heidi Fowler
Psychiatry 25 years experience
This combination can work quite well for a mixed depression or an atypical depression combined with anxiety.
May 11, 2013
Dr. Alan Ali
Dr. Alan Alianswered
Psychiatry 32 years experience
Prozac (fluoxetine): Assuming wellbutrin (bupropion) is at maximum dose and still no response, sometimes Prozac can be booster, taking it in morning & wellbutrin (bupropion) at lunck. Monitor signs of irritability & anxiety.

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Last updated May 10, 2019

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