I'm on 80mg of prozac, 150 mg of seroquil, 10mg brintellex and wellbutrin (bupropion) 100mg twice a day for depression and ocd. my np doesn't want to change any.

Not effective?: Need more information to understand your primary concern - is your concern the regimen is not effective, or too much? or is your concern with the regimen itself? In general I encourage keeping an open line of communication with your provider. If your concerns remain or regimen is ineffective, a second-opinion consult may help to explore treatment options further. Be well.