A member asked:

Is it safe to take tramadol the same day as benadryl (diphenhydramine)? so if i take tramadol at like 7am, may i take benadryl (diphenhydramine) later that evening?

6 doctors weighed in across 2 answers

Sleepy: Both medications can make you sleepy, be careful, don't drive or operate any machinery while on these. But they can be taken.

Answered 1/1/2021

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Dr. Al Hegab answered

Specializes in Allergy and Immunology

Risk of CNS: depression if taken together, way your options, ask your doctor for an alternative, third generation non-sedating antihistamines as desloratadine, would be an option, ask your doctor about it

Answered 3/1/2018

2.7k views

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