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A member asked:
How does long-term (eg 3-yr) opiate use change brain chemistry (assuming used as prescribed)?
5 doctors weighed in across 2 answers
Multiple ways: Long term opiate use leads to opiate dependence. This is associated with structural and functional changes in brain regions involved in the regulation of affect and impulse control, as well as in reward and motivation. Research shows decreased connections between the amygdala, internal ; external capsule, and insula. http://tinyurl.com/mj37fvb some implications could be depression.
Answered 1/21/2014
4.6k views
Yes: There can be changes in chronic opiate usage in the function and changes in the synapses and actually shape of the neurons in the brain. This may lead to change in behavior of the user.There is literature that shows changes in the shape of cells and how the synapses work or function with chronic use.
Answered 9/28/2016
4.5k views
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