Is it possible for adhd medications to change your brain chemistry?

Long term effect: ADHD is treated with medications,it is at this time it does effect brain chemistry,like any other medicines,is effective,in truly diagnose condition,in those children who really need it,once stopped,there is no long lasting change,in unaffected children,however,does have adverse effects while being on the mess.there appears to be no permanent change.caution is always recommended.