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A 50-year-old member asked:

Please explain if it is safe to mix hydrocodone, ibuprofen, and naproxen sodium or aspirin?

2 doctor answers2 doctors weighed in
Dr. Bruce Rothschild
Rheumatology 48 years experience
No: One should neither mix metaphors nor nsaids and Ibuprofen negates the cardioprotective aspects of aspirin.
Dr. Gary-Anthony Lawson-Boucher
Anesthesiology 22 years experience
Mixing meds: First check if your hydrocodone is a mix of Acetaminophen / ibuprofen. If these are not added to the hydrocodone that you were prescribed, then yes, it is safe to combine in doses that is safe. See vicodin or vicoprophen.

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Last updated Jun 25, 2014

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