Take 50mgs of lyrica (pregabalin) 3 times a day for pain & anxiety, and i also take hydrocodone 10/325 for migraines. is it safe to mix?

Be very careful: You are taking a relatively low dose of lyrica, (pregabalin) and may be taking a high dose of hydrocodone for your migraines. You may become very sedated due to taking both. If you have migraines regularly, there are probably better choices than the hydrocodone. You need to regularly consult with your treating physician to coordinate the treatment for these conditions. Be careful, open and honest.