Hello, is it true that the effect of paxil (paroxetine) and wellbutrin both become less or insignificant by the time (work to limit time then not working in body).

It can happen with: Any antidepressant. We do not know why this happens. We also unfortunately do not have any comparative data on the antidepressants in this regard. Clinically i would say that I have seen Prozac last the longest without requiring change (unpublished data from my practice). We have two year data on Paxil (paroxetine) in this regard. When it happens, we augment or switch. Godt nytt år!