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A 33-year-old member asked:

For what reason colon part is usually prone to cancer in hnpcc (hereditary hereditary nonpolyposis colorectal cancer)?

1 doctor answer4 doctors weighed in
Dr. Gurmukh Singh
Pathology 50 years experience
Genetic disorder: Hnpcc also called lynch syndrome results from at least four type of genetic defects involving genes needed for repair of damaged dna. See this site for more info. http://ghr.nlm.nih.gov/condition/lynch-syndrome.

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A 49-year-old member asked:

Why is the colon prone to cancer in hnpcc (hereditary nonpolyposis colorectal cancer)?

1 doctor answer1 doctor weighed in
Dr. Myron Arlen
Surgical Oncology 65 years experience
Genetic mutations: HNPCC or hereditary nonpolyposis colorectal cancer is an autosomal dominant genetic condition that has a high risk of colon cancer The disease first described by Lynch and is associated with other cancers including endometrial ovary and stomach. The increased risk is due to inherited mutations that impair DNA mismatch repair. .Individuals with HNPCC have an 80% lifetime risk for colon ca.

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Last updated Dec 30, 2013
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