In your experience, what is the most common autoimmune or other condition associated with symptomatic cryofibrinogenemia? or is cryofibrinogenemia typically the primary disease process?

Usually primary: Cryfibrinogenemia is usually the primary diagnosis and is associated mainly with vascular issues such as raynauds or cutaneous vasculitis.

Could be either: This disease often starts with skin lesions (ulcers, purple spots, decreased blood flow to fingers/toes). It can either be primary or secondary. When secondary, it's related to cancer, infection (hepatitis c and others), collagen vascular diseases, or vasculitis. Your doctor has to keep all these possibilities in mind. As an oncologist I have seen it as the first sign of cancer.