What to do if i have a big cold sore on my lip and was wondering if i could use orabase on it?

Palliative Only: Orabase will not help the cold sore, except alleviating mild discomfort. What you need for a cold sore (which is the herpes simplex virus) is anti-viral medication. I recommend valcyclovir tabs and Acyclovir topical paste. The dosage determined by your dentist. Remember, "cold sores" are very contagious, to yourself and others! no touching the lesion and eyes, nose, or genitals; no kissing!