Is it possible that a high white cell count be caused by c.o.p.d, a pituitary gland tumour, or female problems?

How high?: A small elevation in the total white count may be perfectly healthy -- reference ranges are set so that several percent of healthy folks fall outside at either end. It's more important to know what the white cells look like, and whether any are abnormal. As a pathologist / lab specialist, i'm always telling folks, "look at the person, not the labs.".