Will nicotine (in the form of ecig not cigarette) cancel out the effects of protein synthesis and building muscle when bodybuilding?

First , muscle is: Basically protein. So why would you want to negate protein synthesis if you are building tissue. Second nicotine whether you eat it, inhale i one way of another or rub it on is still nicotine. Nicotine is a stimulant and released some additional proteins and neurotransmitters in your body. Nicotime is an addictive drug with many unhealthy side effects.