Why doesn't my lipoma shrink with exercise and weight loss?

It's independant: A lipoma is a tumor, usually not cancer. It has no relationship to weight or diet. It grows independently of your food intake or exercise level. The only thing to do is ignore them or have them removed. The bigger they are, the greater the chance of malignancy. 5 cm or larger is malignant until proven otherwise.

Bumps: Lipomas are autonomous fatty tissue growths. Consider it a fat cell gone wild, and are independent from weight gain or loss. Generally, they are enveloped by a capsule and have an independent blood supply relative to the rest of the surrounding fatty tissue. The most important issues are size, growth rate, and the location of your lipoma. Rarely there are malignant liposarcomas.

Good Question: Lipomas are abnormal fatty growths. Why don't they shrink or go away with exercise and weight loss? Unknown. The only known way to get rid of them is to excise them.

Hard to say why: Lipomas seem to grow without any cause (although some studies indicated that some lipomas develop in areas of past trauma). As you lose wt (and fat) the lipoma may actually appear more prominent because there is less surrounding fat to conceal it. The only way to get rid of your lipoma is through surgery.