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A 21-year-old member asked:

Is pulmonary hypertension hereditable?

4 doctor answers7 doctors weighed in
Dr. Arnon Rubin
Internal Medicine 25 years experience
Yes: If you have primary pulmonary hypertension there are several classes of drugs to treat it. Tracleer, (bosentan) revatio, letaris are some of the drugs that can be used in the right situation.
Dr. Lokesh Guglani
Pediatric Pulmonology 22 years experience
Yes and No: Not all forms of pulmonary hypertension are heritable. Pulmonary hypertension can develop due to severe chronic lung or heart disease, chronic thrombotic disorders, sickle cell disease & rare blood vessel disorders. Certain rare types of pulmonary hypertension associated with bmpr-2 mutations are heritable. Please consult a lung specialist for full diagnostic work up.
Dr. Charles Burger
Internal Medicine - Pulmonary Critical Care 37 years experience
It may be inherited: Up to 5% of patients with pulmonary arterial hypertension (pah) may have a genetic or heritable cause. Research studies have identified a genetic abnormality affecting bone morphogenetic protein receptor 2 (bmpr2) that appears to predispose a patient to pah. Fortunately, even if an individual inherits the abnormal gene, the likelihood of developing pah is only 1 in 5.
Dr. Ed Friedlander
Pathology 45 years experience
Usually not: Primary pulmonary hypertension usually strikes at random, without any clear familial tendency. Nobody understands why. Other pulmonary hypertension is secondary to some other lung disease. Best wishes.

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Last updated Jul 7, 2020

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