A member asked:

Negative result for thyroid peroxidase antibodies tpoab . necessary to test my thyroglobulin antibodies tgab ?

2 doctors weighed in across 2 answers
Dr. John Chiu answered

Depends on: Depends on the disease condition you are trying to confirm or rule out. For example, you should get a tgab done also if grave's disease is suspected.

Answered 11/21/2013

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Dr. Michael P Vaughn answered

Specializes in Allergy and Immunology

Anti-thyroglobulin: Studies have shown that 99% of patients with hashimoto's thyroiditis have anti-microsomal antibodies, whereas only about 1/3rd had anti-thyroglobulin antibodies. In addition, 10-20% of persons without thyroid problems have anti-throglobulin antibodies (tg-a). These persons are likely at higher risk for future problems and should be watched more closely however, testing for tg-a is not necessary.

Answered 5/19/2019

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