Will a problem in the liver cause pain in the back?

Liver & back pain?: Generally not. There is too much tissue separating the liver from the spine. The exception is a cancer, which might have a metastasis to both liver and the spine. Similarly, there are other rare infiltrative, metabolic, or disseminated infections that might involve both areas. An exception is a gall bladder problem, which hurts in the same place as the liver; it can send pain to the r shoulder bla.

It can: Yes, this can occur. Also, gallbladder can cause back pain. So can the pancreas and kidney stones. So can muscle spasm, rib dysfunction and a bunch of other things. See your doctor.