A member asked:

Caffeine makes my abilify's blunting affect effects less severe, why?

A doctor has provided 1 answer

Alerting effect: As the day goes on, our bodies build up a chemical called adenosine. As Adenosine climbs, our desire to sleep increases. Our alertness diminishes. Caffeine blocks adenosine, thereby making us more alert. This is the mechanism underlying what you are feeling when you drink caffeine while on Abilify (aripiprazole) because Abilify (aripiprazole) does have a sedating effect.

Answered 6/24/2014

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Esgic (acetaminophen butalbital and caffeine) for severe headache?

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