A member asked:

How do dopamine antagonist help opioid nausea if opioid nause is mediated through opioid receptors and not dopamine?

A doctor has provided 1 answer

interrelated: All receptor systems are interrelated and interact with each other. Whatever induces nausea, the reaction is triggered by dopaminergic pathways in a part of the brain called the chemoreceptor trigger zone. Most anti-emetics work by antagonizing dopamine. The combination of opioids and antinausea medications is quite common, both for synergism and to reduce nausea.

Answered 10/18/2013

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