A member asked:

What p450 enzymes are inhibited/induced by seroquel, (quetiapine) and what does a dopamine/norepinephrine antagonist do? reduce dopamine levels? specifics please?

7 doctors weighed in across 2 answers
Dr. William Harris answered

Specializes in Family Medicine

Neither: Seroquel (quetiapine) passes through the cyp450 3a4 pathway & is extensively metabolized, but it neither inhibits nor induces the pathway itself. On the other hand, it's metabolism may be significantly affected by other medications. For instance, Dilantin induces the pathway causing seroquel (quetiapine) to be rushed through the pathway, leading to less-effective, lower blood levels. Antagonists are blockers.

Answered 2/10/2017

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Dpoa/norepi: to answer that part of your question: the agents don't decrease the amount of the neurotransmitters in your body but actually compete for the receptors that they need to bind to to cause their effect.

Answered 5/29/2017

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