A member asked:

Can zoloft (sertraline) decrease the effects of adderall? or could i be gaining a tolerance to adderall?

5 doctors weighed in across 2 answers
Dr. Pamela Pappas answered

Specializes in Psychiatry

Not decrease: In some cases zoloft (sertraline) can accentuate -- not decrease -- the effects of stimulants. Please discuss these issues with your psychiatrist.

Answered 10/4/2013

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Dr. Heidi Fowler answered

Specializes in Psychiatry

Agree w Dr. Pappas.: Per Drugs.Com drug interaction checker - drug interaction checker > Adderall (amphetamine / dextroamphetamine) plus Zoloft (sertraline) may ^ risk for serotonergic syndrome. May also ^ side effects of nervousness, anxiety, racing thoughts and restlessness. However, it is usually safe together.

Answered 3/29/2020

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