Question 1

i have persistent polyclonal b cell activation, raised igm and systemic flu like symptoms but docs are confused. no monoclonal bands, bence jones proteins or light chains. fbc normal. negative, ebv, cmv, strep, hiv, hepatitis, syphilis. please help?

Accepted Answer

: What kind of docs are confused? Best to see an oncologist.

Question 2

does raised immunoglobulin m (igm) mean i have some disease?

Accepted Answer

High IgM: This is typically normal if seen on any one spot check. If it is high repeatedly on two or more checks, a test called " immunofixation" should be ordered to be sure it is not coming from only one population of blood cells; rarely, this could be due to a monoclonal gammopathy (a pre-cancerous condition).  Or even rarer, a blood cell cancer called multiple myeloma.

Question 3

i am being tested for lupus my aptt ratio was 1.16 slightly raised  and my cardiolipin igm was 102ug/l esr raised but ana was normal.

Accepted Answer

Need more data : This will depend on more information that I have at this point. then ANA could be negative if only a binding essay was used rather than an immunofluorescent assay.  You may fulfill criteria for lupus anticoagulant . You will need to have your physician clarify these tests which Lab did them and how accurate  they are.

Question 4

what are cd4+ t cells? and what does it mean if they are raised? i have mbl deficiency, low igm & igg3. raised crp & serum amyloid a

Accepted Answer

Cd4 are lymphocytes: cd4 stands for cell determinant 4 which is a protein in the cell membrane.  Cd4 are lymphocytes that help modulate the response in cellular immunity. Deficiencies in cell mediated immunity predisposes patients to infections like Pneumocystis jirovechi

Question 5

i saw my gp about my cardiolipin igm which has been high 3x.gp dismisses any further actions, aspirin or tests. my neutrophils have been raised also.

Accepted Answer

See details: It would be helpful if you could post the normal range for the test and your specific values. Mildly elevated test values mean nothing. If you are concerned, see a hematologist.

Question 6

my cardiolipin igm has come back high 3 times, neutrophils slightly raised & ana negative. symptoms indicative of lupus, mctd?? gp not worried.

Accepted Answer

See a rheumatologist: The lab tests may be unreliable especially at hospital labs.  Even if negative the anticardiolipin ab may be a concern depending on your symptoms.  IgM anticardiolipin Anyibody us also for many not a problem.  It us best if you are having symptoms to see a specialist and get their opinion.

Question 7

lyme elisa was positive but western blot negative. i have flu like symptoms with fevers, sore glands, raised igm (general) and positive ana, negative for ebv,cmv, tb,hiv, hepatitis, syphilis, strep, h pylori, vsv. is this lyme? if no what could it be?

Accepted Answer

: Histoplasmosis if you raise pigeons or spelunk.  Did you have classical skin rash of Lyme.  Is Lyme common where you live or were visiting before you got ill. Complex blood work. Discuss with a Internist (lymphoa?),  rheumatiologist (lupus) or ID dr (other infections common where you are).  Work with your team.

Question 8

what are causes of elevated igm?

Accepted Answer

IgM: Igm is our first defense against bacteria, so if you have an active infection it can be the cause of this elevation. A chronically elevated igm may indicate an immunodeficiency. An immunologist can help you make the diagnosis. In rare cases it can be a malignancy.

Question 9

when should a igg vs a igm test be ordered?

Accepted Answer

IgM vs. IgG: Igm tests are typically ordered when an infection is thought to be present for one week or more. Igm levels often disappear within the first few months. Igg testing is typically ordered when the infection has been thought to be present for 2 or more weeks. Igg levels my stay elevated for years after an infection has resolved.

Question 10

what does anti hbcag-igm non reactive means?

Accepted Answer

Negative: It means you do not have an acute (or recent) infection of hepatitis b virus.

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Doctor answers about:

Raised igm

A member asked:

I have persistent polyclonal b cell activation, raised igm and systemic flu like symptoms but docs are confused. no monoclonal bands, bence jones proteins or light chains. fbc normal. negative, ebv, cmv, strep, hiv, hepatitis, syphilis. please help?

A member asked:

Does raised immunoglobulin m (igm) mean i have some disease?

A member asked:

I am being tested for lupus my aptt ratio was 1.16 slightly raised and my cardiolipin igm was 102ug/l esr raised but ana was normal.

A member asked:

What are cd4+ t cells? and what does it mean if they are raised? i have mbl deficiency, low igm & igg3. raised crp & serum amyloid a

A member asked:

I saw my gp about my cardiolipin igm which has been high 3x.gp dismisses any further actions, aspirin or tests. my neutrophils have been raised also.

A member asked:

My cardiolipin igm has come back high 3 times, neutrophils slightly raised & ana negative. symptoms indicative of lupus, mctd?? gp not worried.

A member asked:

Lyme elisa was positive but western blot negative. i have flu like symptoms with fevers, sore glands, raised igm (general) and positive ana, negative for ebv,cmv, tb,hiv, hepatitis, syphilis, strep, h pylori, vsv. is this lyme? if no what could it be?

A member asked:

What are causes of elevated igm?

A member asked:

When should a igg vs a igm test be ordered?

A member asked:

What does anti hbcag-igm non reactive means?

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