Question 1

what is mild polyclonal gammopathy that's what the dr said i have but i haven't seen him yet?

Accepted Answer

Means little alone: You have more antibodies on board than most people. Maybe you're just getting over an illness, or it's your celiac disease, or it's just you. This is meaningful only as part of a workup for other illness.

Question 2

i was diagnosed with ra a couple years ago. just did ife and pe serum and it is suggested an apparent polyclonal gammopathy. what is that?

Accepted Answer

Active immune system: The part of blood that contains antibodies is gamma globulin.  Polyclonal refers to the fact that many different antibodies are present.  The increase in quantity reflects a broadly activated immune system cranking out lots of antibodies.  This is common in autoimmune disease and is not a concern.

Question 3

how does having polyclonal gammopathy correlate with lupus- i have lupus and polyclonal gammopathy does having this mean you have a more severe form of lupus, they did an spep be4 lupus and i had that?

Accepted Answer

Not really!: Many patients with lupus have polyclonal gammopathy, or elevation of multiple gammaglobulins, iga, igg, and igm. There is a modest association with severity, not not alwayws.  The gammaglobulins will usually fall with successful therapy!

Question 4

does ebv (mono) cause polyclonal gammopathy?

Accepted Answer

It can but...: Polyclonal gammopathy is an exaggerated immune response which can be triggered by a variety of infections and EBV can be a cause but it's unusual. Even if you have EBV I'd check for other infections like Lyme disease and parasites that could cause EBV to be unusually severe. I advise seeing a good integrative/functional medicine Dr. 
See https://www.arthritisresearch.us/immune-response/j-kyq.html

Question 5

in protein's electrophoresis is polyclonal gammopathy alway pathological? thanks

Accepted Answer

Need more info: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, What is total gamma globulin level? If it is more than 2.0 gm/dL it needs to be evaluated. There are many causes of polyclonal gammopathy., and some of those are serious.

Question 6

can cystic fibrosis exhibits polyclonal gammopathy?

Accepted Answer

Yes: This is common because of the frequent bacterial infections.

Question 7

what does elevated igg-2364 and gamma globulin 2.2 mean with polyclonal gammopathy and kappa and lambda typing increased?

Accepted Answer

Need more info: What is your medical condition?  Per se, polyclonal increases in IgG does not mean much although it may indicate the presence of a chronic infection if there is sign of infection.

Question 8

what does a polyclonal gammopathy, kappa and lamdba type, with an elevated alpa-2, beta, iga, crp, and sedimentation rate indicate?

Accepted Answer

Inflammation: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Talk to the doctor who ordered the tests. Having said that, the results you provided suggest chronic inflammation. None of the tests you listed provide a specific diagnosis.

Question 9

can you explain what this might mean: "apparent polyclonal gammopathy: igm.  kappa and lambda increased".  immunoglobulin m is also high at 437.?

Accepted Answer

Monoclonal processes: Are often malignant or pre malignant.  Polyclonal processes are usually reactive/infectious/inflammatory.

Question 10

an apparent polyclonal gammopathy: iga. kappa and lambda typing appear increased. what does this mean? im being referred to a hematologist, do i have cancer?

Accepted Answer

: Discuss with Hematologist and your Drs.. Why was the test done?  Don't know enough details to be able to help.

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Doctor answers about:

Polyclonal gammopathy symptoms

A member asked:

What is mild polyclonal gammopathy that's what the dr said i have but i haven't seen him yet?

A member asked:

I was diagnosed with ra a couple years ago. just did ife and pe serum and it is suggested an apparent polyclonal gammopathy. what is that?

A member asked:

How does having polyclonal gammopathy correlate with lupus- i have lupus and polyclonal gammopathy does having this mean you have a more severe form of lupus, they did an spep be4 lupus and i had that?

A member asked:

Does ebv (mono) cause polyclonal gammopathy?

A member asked:

In protein's electrophoresis is polyclonal gammopathy alway pathological? thanks

A member asked:

Can cystic fibrosis exhibits polyclonal gammopathy?

A member asked:

What does elevated igg-2364 and gamma globulin 2.2 mean with polyclonal gammopathy and kappa and lambda typing increased?

A member asked:

What does a polyclonal gammopathy, kappa and lamdba type, with an elevated alpa-2, beta, iga, crp, and sedimentation rate indicate?

A member asked:

Can you explain what this might mean: "apparent polyclonal gammopathy: igm. kappa and lambda increased". immunoglobulin m is also high at 437.?

A member asked:

An apparent polyclonal gammopathy: iga. kappa and lambda typing appear increased. what does this mean? im being referred to a hematologist, do i have cancer?

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