A member asked:

How does having polyclonal gammopathy correlate with lupus- i have lupus and polyclonal gammopathy does having this mean you have a more severe form of lupus, they did an spep be4 lupus and i had that?

6 doctors weighed in across 3 answers
Dr. Thomas Namey answered

Specializes in Rheumatology

Not really!: Many patients with lupus have polyclonal gammopathy, or elevation of multiple gammaglobulins, iga, igg, and igm. There is a modest association with severity, not not alwayws. The gammaglobulins will usually fall with successful therapy!

Answered 6/6/2013

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See details: Polyclonal gammopathy is an indicator of inflammation but is not that reliable an indicator of disease severity.

Answered 6/6/2013

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Dr. Liawaty Ho answered

Specializes in Hematology and Oncology

Polyclonal gamma pat: Polyclonal gammoparhy is seen frequently in chronic inflammation/ autoimmune disorder etc. Lupus is certainly one of the condition that causes/ associated with polyclonal gammopathy . The presence of polyclonal gammopathy does not tell you whether the lupus will be more severe or less severe . Discuss with your rheumatologist further.

Answered 3/1/2018

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