Question 1

can you have lupus with completely normal bloodwork? ana, ena neg, complement levels normal, cbc normal. esr of 2 and normal crp

Accepted Answer

ANA negative lupus: There is an entity called ANA negative lupus. Please visit this site for diagnostic criteria for SLE. From what you have described, it is unlikely that you have lupus.

http://www.lupusresearchinstitute.org/lupus-facts/lupus-diagnosis

Question 2

anti phospholipid igg was mildly elevated and esr was 71. lupus anticoagulant was negative. crp was high normal. had bad sinus infections.worry?

Accepted Answer

Not about this: Huge numbers of otherwise-healthy people have low-titer antiphospholipid antibodies. The C-reactive protein is of some use in specific circumstances, and is high in advanced atherosclerosis which I trust you do not have. I'd be thankful for good health and address the sinus and facial pain issues. Best wishes.

Question 3

my lupus flares are skin manifestation only(malar rash)plus fatigue.but esr n crp keeps coming normal including ana.on plaquenil (hydroxychloroquine). was dx not correct?

Accepted Answer

Lupus: Lups is a very difficult diagnosis to make correctly, since there are many diagnostic criteria, and test results are not 100% accurate for this condition. However, as the malar rash and fatigue are your only symptoms, I would at least get a second opinion from a board-certified rheumatologist, perhaps who specializes in Lupus. Since it's a chronic condition, you want to be sure you have it right.

Question 4

went in for joint pain, sun rash, headaches and severe fatigue. blood work-crp 8, esr normal. rdw 16.3% w/ mchc 30.7 but hgb & hct normal. positive for ebv antibodies, no recent infection and negative on mono. ana speckled @ 1:160.  any ideas? lupus?

Accepted Answer

: More information is need to make a diagnosis of lupus.
Visit this site for information and consult a rheumatologist: https://sliccgroup.org/research/sle-criteria/
Wish you good health!

Question 5

can crp and esr tests determine if you have lupus?

Accepted Answer

No: These studies test for the presence of inflammation from any source. They are not specific for lupus. They can be grossly used to measure how active the lupus is.

Question 6

can inflammation from a severe lupus flare cause an elevated d dimer of 1600? crp over 200. esr 50.

Accepted Answer

See below: Elevated CRP and ESR can be signs of lupus glare up. Lupus can cause hypercoagulable state (meaning you can form clots in the body even if you don't need to). D- dimer is a test for to check for by products of clots in the body. Elevated d dimer needs to be attended by doctor asap.

Question 7

esr: 27 ,  crp : 9.2 , ana : 1/80 i don't think these are high enough to say this is lupus, but am i crazy to think this might not just be fibro?

Accepted Answer

yes: It may be many things or nothing significant. These are non-specific tests, as opposed to rafactor;lecells, and others which define autoimmune diseases. But some autoimmune disorders remain vague, do not progress, are rarely disabling but cause discomfort. Often called dyscollagenosis. Recent studies on fibrimyalgia found flaws in the immune system and so this disorder may wind upinthe autoimmune.

Question 8

with recent blood tests indicating detectable (ie. high) levels of crp, ana and esr, should i seek testing for lupus or any other diseases?

Accepted Answer

A good idea,,, : That would be a good idea, given your history of hashimoto's, and especially if you have symptoms and signs like a "butterfly" rash on your face and joint pain/discomfort.

Question 9

how do antihistamines & other antinflammatories taken longterm affect accuracy of esr,crp, ptt tests when r/o lupus or other ctd's?

Accepted Answer

Little or none: ESR (sed rate) and C-reactive protein are actually of little real use in the lupus workup, and the public and physicians set too much by them generally. PTT is used to look for the "lupus anticoagulants" that paradoxically cause thrombosis. The common meds that affect small molecules like histamine and prostaglandins don't impact production of the proteins involved in these tests, or lupus testing

Question 10

when lupus is being treated with plaquenil (hydroxychloroquine) does crp, esr go down & does positive ana turn negative?

Accepted Answer

Yes and no: The ANA usually remains positive throughout and is not related to disease activity. The ESR and CRP will usually fall as disease control improves.

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Doctor answers about:

Lupus with normal esr and crp

A member asked:

Can you have lupus with completely normal bloodwork? ana, ena neg, complement levels normal, cbc normal. esr of 2 and normal crp

A member asked:

Anti phospholipid igg was mildly elevated and esr was 71. lupus anticoagulant was negative. crp was high normal. had bad sinus infections.worry?

A member asked:

My lupus flares are skin manifestation only(malar rash)plus fatigue.but esr n crp keeps coming normal including ana.on plaquenil (hydroxychloroquine). was dx not correct?

A member asked:

Went in for joint pain, sun rash, headaches and severe fatigue. blood work-crp 8, esr normal. rdw 16.3% w/ mchc 30.7 but hgb & hct normal. positive for ebv antibodies, no recent infection and negative on mono. ana speckled @ 1:160. any ideas? lupus?

A member asked:

Can crp and esr tests determine if you have lupus?

A member asked:

Can inflammation from a severe lupus flare cause an elevated d dimer of 1600? crp over 200. esr 50.

A member asked:

Esr: 27 , crp : 9.2 , ana : 1/80 i don't think these are high enough to say this is lupus, but am i crazy to think this might not just be fibro?

A member asked:

With recent blood tests indicating detectable (ie. high) levels of crp, ana and esr, should i seek testing for lupus or any other diseases?

A member asked:

How do antihistamines & other antinflammatories taken longterm affect accuracy of esr,crp, ptt tests when r/o lupus or other ctd's?

A member asked:

When lupus is being treated with plaquenil (hydroxychloroquine) does crp, esr go down & does positive ana turn negative?

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