Question 1

what is holoprosencephaly?

Accepted Answer

Holoprosencephaly: Holoprosencephaly is a serious central nervous abnormality where the brain does not form normally. It can be associated with chromosomal abnormalities which causes newborns to die, such as trisomy 13.

Question 2

semilobar holoprosencephaly, what is this?

Accepted Answer

Holoprosencephaly: is a disorder of varying degrees which results from failure of the brain to appropriately divide during the first several weeks of pregnancy.  The semilobar form indicates that some division did occur, and it is considered an intermediate form.

Question 3

could anyone tell me what holoprosencephaly is?

Accepted Answer

Undivided brain: Most of us have 2 halves in our brain, known as "hemispheres".  Holoprosencephaly (HPE) is abnormal division of the embryo's brain and lack of separation of the cerebral hemispheres. HPI can be mild to severe and can cause defects in the development of the face and in brain structure and function.

Question 4

what happens if holoprosencephaly malformation complex?

Accepted Answer

Brain Development: When the embryo's forebrain does not divide to form bilateral cerebral hemispheres (the left and right halves of the brain), it causes defects in the development of the face and  in brain structure and function.
In less severe cases, babies are born with normal or near-normal brain development and facial deformities that may affect the eyes, nose, and upper lip.The condition can be mild or severe.

Question 5

what is alobar holoprosencephaly?

Accepted Answer

Alobar holoprosencep: it is a rare and serious genetic malformation of the brain with adverse short and long outcome

Question 6

hi doctors, was just wondering what is alobas holoprosencephaly?

Accepted Answer

Lobar Holopreosenceh: I believe you are referring to Lobar Holopreosencehaly in which the brain is not formed well leading to severe mental retardation. This is a rare condition from failure of the brain to completely divide into two separate halves. Many parts of the entire brain may be fused and not allow normal function. This may be as a result of some chromosomal disorders. A more complete descriptionfromgeneticist

Question 7

what is the average life expectancy for a child with holoprosencephaly?

Accepted Answer

Undetermined: Potential depends on the severity of the defect and associated features. Many die before birth and most have a brief existence.The defect involves a great range from very major to minor, with longevity matching the degree of defect. See www.ninds.nih.gov/disorders/holoprosencephaly  for more information

Question 8

how is holoprosencephaly malformation complex caused?

Accepted Answer

Neuronal migration.: Holoprosencephaly is a developmental anomaly typically found in trisomy 13 (patau syndrome) and associated with neuronal migration anomalies resulting in fusion of the cerebral ventricles and hemispheres.

Question 9

what other genetic problems might someone have if they have a child with holoprosencephaly?

Accepted Answer

Multiple: Holoprosencephaly is seen frequently with trisomy 13. It is also found in partial chromasome deletion syndromes for 11, 13 &18. One of my few cases was an affected fraternal twin that also had  21 trisomy Down syndrome (the other twin was normal).

Question 10

is there any hope for babies with lissencephaly, porencephaly, holoprosencephaly?

Accepted Answer

Yes, some.: The fetal/neonatal brain has enough plasticity to allow for mild/moderate porencephalic cases to function at an acceptable level after a long and hard road to recovery. Lissencephaly and holoprosencephaly are developmental disorders of the brain anatomy and usually are manifested with recalcitrant seizures, profound neurodevelopmental delay and limitations to independent living.

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Semilobar holoprosencephaly, what is this?

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Could anyone tell me what holoprosencephaly is?

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What happens if holoprosencephaly malformation complex?

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What is alobar holoprosencephaly?

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Hi doctors, was just wondering what is alobas holoprosencephaly?

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What is the average life expectancy for a child with holoprosencephaly?

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How is holoprosencephaly malformation complex caused?

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What other genetic problems might someone have if they have a child with holoprosencephaly?

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Is there any hope for babies with lissencephaly, porencephaly, holoprosencephaly?

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