Question 1

complement c4 is .12 (normal is .14 -.54) is it worth getting repeated.

Accepted Answer

Yes, piece of mind: Complement deficiency is rare but requires a fairly extensive work-up by an immunologist. A simple repeat of this test could offer some direction particularly if asymtomatic.

Question 2

what could high immunoglobulin ig m and complement c4 mean?

Accepted Answer

May be significant: Immunogloblin m (igm) is one of the 5 classes of proteins that have antibodies. C4 is part of the complement cascade, a series of proteins that are important in immunity and inflammation. Elevation of both may occur in various diseases. The significance of the specific values for you depends on what your clinical problem is. Therefore, i can not be more specific as to what it means for you.

Question 3

what does it mean when you have high levels of complement c4 and sedimentation rate westergren?

Accepted Answer

Complement C4/ESR: complement C4 and the erythrocyte sedimentation rate are usually high in conditions which cause acute or chronic inflammation. These are often measured in autoimmune diseases and rheumatoid arthritis, but they can be elevated in many other conditions, including cancer and heart attacks. The results need to be interpreted by your physician. Good luck.

Question 4

i have a complement c4 of 8 and c3 of 65. also have positive ana 1:80 homogeneous. what could this indicate? lupus?

Accepted Answer

See below: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, low serum complement and positive ANA suggest auto-immune disorder. A more precise diagnosis needs more information and maybe more tests.

Question 5

high positive ana for years and now tested elevated complement c4 and c3 but all other autoimmune antibodies are still negative. what could that be?

Accepted Answer

Inflammation: Complement is a phase reactant which means it will go up with any type of inflammation.  It is not specific for any one problem.  A low complement is of more concern.  These lab texts could mean you will eventually develop an autoimmune disease or other disease process associated with ANA.  They slso may never amount to anything.

Question 6

what can cause the sedimentation rate-westergren - 70; complement c4, serum - 53; immunoglobulin m, qn, serum - 36; complement, total (ch50)	>63?

Accepted Answer

Inflammation: Your lab studies point to inflammation but do not reveal the cause which should be evaluated by your doctor.

Question 7

complement c3 & c4 tests done 3 times. c3 normal but twice c4 was borderline normal or borderline low, 3rd time it was well within range. deficiency?

Accepted Answer

Why the tests?: If the values were either borderline low or borderline normal, then one would call the value low normal. Whether it means anything or not would depends on whether you have a disease condition associated with complement consumption.    A low C4 is usually found in patients with hereditary angioedema.

Question 8

rnp antibody, speckled pattern, titer of 1:320.  no symptoms or anything. high complement c3 & c4 levels. do i have an autoimmune disease?

Accepted Answer

Not necessarily: Do you have any symptoms? If you do not, stay in touch with your doctor for follow-up care. An abnormal lab results does not make it auto-immune disease, but it does put you at a greater risk.
Avoid exposure to sun.

Question 9

went for urinalysis test - all ok but complement c3 & c4 serum low and total iga high. hv hep c n cirohsis, low bp, taking diuretic. pl advice?

Accepted Answer

Seriously sick: You know this. I'm glad you are alcohol-free. If you are a candidate for one of the new treatments to try to eliminate hepatitis c, please consider trying. The high IgA and the lowish complement components fit with your progressing liver disease. Your physician can advise you about medication. If the virus is eliminated, your liver will largely heal. Best wishes.

Question 10

increased aldolase,  complement c3/c4 serum, sed rate, c-react. protein, beta globulin, monocytes, bun/creatin low mcv-mch, vit d-possible causes?

Accepted Answer

Complicated: When i was doing clinical medicine, these were collectively sort of the flags for sarcoid disease but I am not saying that's the case here. This is because sarcoid is a diagnosis of exclusion so the advice is to rule out other diseases with additional diagnostic tests which can be done by a primary care physician or rheumatologist.

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Doctor answers about:

Complement C4

A member asked:

Complement c4 is .12 (normal is .14 -.54) is it worth getting repeated.

A member asked:

What could high immunoglobulin ig m and complement c4 mean?

A member asked:

What does it mean when you have high levels of complement c4 and sedimentation rate westergren?

A member asked:

I have a complement c4 of 8 and c3 of 65. also have positive ana 1:80 homogeneous. what could this indicate? lupus?

A member asked:

High positive ana for years and now tested elevated complement c4 and c3 but all other autoimmune antibodies are still negative. what could that be?

A member asked:

What can cause the sedimentation rate-westergren - 70; complement c4, serum - 53; immunoglobulin m, qn, serum - 36; complement, total (ch50) >63?

A member asked:

Complement c3 & c4 tests done 3 times. c3 normal but twice c4 was borderline normal or borderline low, 3rd time it was well within range. deficiency?

A member asked:

Rnp antibody, speckled pattern, titer of 1:320. no symptoms or anything. high complement c3 & c4 levels. do i have an autoimmune disease?

A member asked:

Went for urinalysis test - all ok but complement c3 & c4 serum low and total iga high. hv hep c n cirohsis, low bp, taking diuretic. pl advice?

A member asked:

Increased aldolase, complement c3/c4 serum, sed rate, c-react. protein, beta globulin, monocytes, bun/creatin low mcv-mch, vit d-possible causes?

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